Deleteriousness of Neanderthal DNA in Modern Humans

Homo Neanderthalensis, adult male. Reconstruction based on Shanidar 1 by John Gurche. Photo credit: Smithsonian National Museum of Natural History

*Homo Neanderthalensis, adult male. Reconstruction based on Shanidar 1 by John Gurche. Photo credit: Smithsonian National Museum of Natural History

 

Modern Europeans on average have about 3% Neanderthal ancestry. However, this ancestry is not distributed evenly across our genomes. This indicates that selection is working on Neanderthal DNA differently than on modern European DNA. In this work we seek to understand the distribution of selection effects in the Neanderthal DNA in current modern humans. Additionally we are interested in how gene expression is affected by Neanderthal DNA.

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